American Heart Association press release with the announcement made by the signatories of a recent study of Harvard University 's Massachusetts General Hospital, Associate Professor in the running. Dr.. Hakan Ay and his team , regardless of the vessels of the brain that reaches every point and that a neural network structure from various points outside the body as a result of electrical stimulation of brain injury can be reduced by giving showed.
Remain anemic against brain is the organ most vulnerable. Blood flow in the brain is interrupted for any reason, to come back minutes to 1.9 million brain cells will be lost. Brain death and long-term vascular occlusion nowadays is one of the leading causes of disability. Obstruction of brain vessels connected to the past 20 years , numerous studies to prevent brain damage done , but has not yet found an effective treatment method. One of the most important causes of failure , given by intravenous drugs due to clogged arteries which remained anemic reach the region and in this region it is impossible to gain access to sufficient quantities.
Results of electrical stimulation through Providing brain injury can be decreased
I wonder in case of vascular occlusion in the human body to protect the brain there is a built-in system ? Harvard University's Massachusetts General Hospital, Associate Professor in the running. Dr.. Hakan Ay and his team first evidence of the existence of such an internal system to have reached. Dr.. Moon and his team , regardless of vessels of the brain that reaches every point and that a neural network structure from various points outside the body as a result of electrical stimulation of brain injury can be reduced by giving showed. The team's results of his studies in experimental animals in America last week, the city of San Diego International Conference on Cerebrovascular Diseases by the American Heart Association has been declared a special press release.
" Vagus Nerve Function of the brain was also shown to control "
Dr.. Dr.. Hakan Ay and his team , who nerve in the human body the longest and most important branches of the vagus nerve to the brain and this warning electrically stimulate the brain damage as a result of anemia showed that reduced by half. Dr.. Month, were found in the following statement on the subject : " The vagus nerve , brain, intestine until all the internal organs contained controls. This nerve stimulation to decrease heart rate , low blood pressure and a kind of physical and mental relaxation and relief causes. The vagus nerve is also known as the nervous therefore life. Vagus nerve fibers in recent years not only the heart, lungs , liver , kidneys, and internal organs such as bowel , but also has shown to control the brain function. "
Methods of Reducing Brain Damage
Dr.. Hakan Ay and his team of the vagus nerve , the nerve that appear on the skin in a small area of the external ear canal occluded vessel after 1 hour of stimulation showed that significantly reduce brain damage. Dr.. Moon, " also from the neck of the nerve as it passes through the skin in accordance with , the observed similar effects on the brain , he said. Dr.. Month , " the severity of the warnings given by this method is very low and hardly can be felt by the patient ," he said.
More patients at home or in an ambulance whilst a viable method
Dr.. Month, added the following : " From the outside without medication , the brain 's internal systems to mobilize against a deadly disease such as stroke and increasing the resistance of the brain is an entirely new concept. If shown to be effective in humans , this treatment method can be applied while the patient is more at home or in the ambulance will enable early intervention and vascular occlusion depend on it will significantly reduce the loss of brain tissue. "
Applying this method in Animal Experiments, Or is it done?
Dr.. Month, also gave the following information : " Vagus nerve stimulation ( VNS) for 20 years, drug-resistant epilepsy in humans and is used as an FDA-approved to treat depression. This method for treating epilepsy and depression is being implemented with the help of a device implantable. I.e. opened and neck surgery , nerve be discovered and is placed on the nerve stimulating electrode , and these electrodes are about 5-6 cm in diameter, is connected a battery placed under the skin of the chest is maintained. VNS until now has been used successfully in hundreds of thousands of patients. Electrical stimulation in epilepsy and depression every 5 minutes is a lifetime. Does not have a serious side effect of treatment.
Our group also useful in the treatment of cerebral vascular occlusion , and it would be the first to propose mechanisms in a detailed way in the last 10 years has been the first group of employees. First, as has been done in your group of epilepsy and depression " implantable " started working with the device and this device in animal models of cerebral vascular occlusion flatten the neck by inserting applied on the nerve. These studies damage to the vagus nerve stimulation in the brain showed a 50 percent decrease. However to achieve this effect treatment within a few hours after the onset of atherosclerosis must be provided. This very rapid surgical approach is not practical in humans. Therefore , our group does not require invasive interventions to stimulate the vagus nerve, more simple ways to begin research. There are two points of the body surface where the nerve is approached. They are one of the outer ear and the other is under the skin in the neck. Our group of experimental animals from these two points , and that stimulation of the nerve to be induced in the brain have demonstrated a protective effect. In addition to superficial stimulation in humans has led to the development of technology that can be used. These technologies have begun to be tested in humans by our group. First headset with surface electrodes in humans in the form of advanced technology accompanied by MR imaging methods have been applied in the alert has been shown to increase cerebral blood flow. Sudden blockage of these technologies in patients with cerebrovascular Harvard center study to test the initial stage.
Faculty member at Harvard İlknur Month
Applying this method if the Success Rate How Much?
VNS in patients with superficial vein occlusion sudden brain is not yet implemented. However, the lack of side effects when used in other indications and warning superficial nowadays due to the development of the technology necessary for human trials will start at great speed. In brain vascular occlusion lifelong warning is given not only for 1 hour. Given the severity of warning for epilepsy and depression, which is similar in serious side effects are expected.
Experimental animal studies also İlknur months , which was made by my wife. He has been working as a faculty member at Harvard like me. Therefore, the development of this technology mainly a Turkish team would not be wrong to say that. In this project, students from many different countries , trainees and technicians have been working with us. "
Dr.. Hakan Ay and his team to determine the optimal excitation properties continues to work.
Prof. Dr.. Hakan Ay Who is he?
I'm currently connected to Harvard University at the Massachusetts General Hospital Department of Radiology and Neurology in both works as Associate Professor. Since 1996, except for a period of three years at Harvard 's. Invention in the field of neurology and has scored many important concepts. Over 100 articles and books have been published in major medical journals. Studies so far received over two thousand citations. The Lancet , Circulation, and a total of 15 different Annals Neuroloj the respected medical journal refereeing , the most important in the world in the field of cerebrovascular disease in two journals in making editorial board member. In 2009, "American Heart Association" in the field of vascular disease by medicine given to individuals who have made significant contributions to the FAH was awarded with the title. Numerous independent research organization supported by the research support was awarded with prizes.
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